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Alice Y W Chang Selected Research

Mevinphos

9/2017PTEN, a negative regulator of PI3K/Akt signaling, sustains brain stem cardiovascular regulation during mevinphos intoxication.
1/2015Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication.
3/2014Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication.
9/2013Transition from oxidative stress to nitrosative stress in rostral ventrolateral medulla underlies fatal intoxication induced by organophosphate mevinphos.
11/2009Brain stem death as the vital determinant for resumption of spontaneous circulation after cardiac arrest in rats.
4/2005Coenzyme q10 confers cardiovascular protection against acute mevinphos intoxication by ameliorating bioenergetic failure and hypoxia in the rostral ventrolateral medulla of the rat.

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Alice Y W Chang Research Topics

Disease

12Hypotension (Low Blood Pressure)
09/2017 - 05/2003
8Endotoxemia
09/2016 - 01/2002
6Status Epilepticus (Complex Partial Status Epilepticus)
02/2014 - 10/2004
5Brain Death (Brain Dead)
09/2016 - 01/2011
5Hypertension (High Blood Pressure)
11/2013 - 02/2009
4Seizures (Absence Seizure)
08/2020 - 04/2009
4Hypoxia (Hypoxemia)
03/2011 - 04/2005
4Mitochondrial Diseases (Mitochondrial Disease)
11/2009 - 10/2004
3Epilepsy (Aura)
08/2021 - 12/2010
3Neoplasms (Cancer)
10/2016 - 03/2015
3Poisoning
03/2014 - 05/2007
3Bradycardia
10/2006 - 04/2005
2Insulin Resistance
08/2021 - 06/2014
2Stroke (Strokes)
07/2021 - 11/2014
2Dementia (Dementias)
07/2021 - 11/2015
2Esophageal Squamous Cell Carcinoma
10/2016 - 03/2015
2Coma (Comas)
09/2016 - 01/2011
2Inflammation (Inflammations)
01/2016 - 06/2015
2Neuroinflammatory Diseases
06/2015 - 11/2014
1Drug Resistant Epilepsy
08/2021
1Cognitive Dysfunction
07/2021
1Partial Epilepsies (Epilepsy, Partial)
08/2020
1Aneurysm (Aneurysms)
01/2016
1Aortic Aneurysm (Aneurysm, Aortic)
01/2016
1Carcinogenesis
01/2015
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
11/2014
1Ischemic Stroke
11/2014

Drug/Important Bio-Agent (IBA)

9Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
09/2017 - 07/2005
9Proteins (Proteins, Gene)FDA Link
03/2015 - 09/2002
8LipopolysaccharidesIBA
06/2015 - 09/2002
7Peroxynitrous Acid (Peroxynitrite)IBA
09/2017 - 07/2005
7Superoxides (Superoxide)IBA
11/2013 - 05/2003
7EnzymesIBA
04/2012 - 01/2002
6MevinphosIBA
09/2017 - 04/2005
6Nitric Oxide Synthase (NO Synthase)IBA
02/2014 - 07/2005
5coenzyme Q10 (CoQ10)IBA
08/2021 - 05/2003
5Cytochromes c (Cytochrome c)IBA
07/2012 - 01/2002
4Angiotensin IIIBA
10/2016 - 11/2013
4OrganophosphatesIBA
03/2014 - 04/2005
4Nitric Oxide (Nitrogen Monoxide)FDA Link
07/2010 - 04/2007
3Reactive Oxygen Species (Oxygen Radicals)IBA
06/2015 - 10/2009
3Caspase 3 (Caspase-3)IBA
02/2014 - 04/2007
3UbiquitinIBA
04/2012 - 01/2011
3Propofol (Diprivan)FDA LinkGeneric
01/2009 - 04/2004
2AntioxidantsIBA
08/2021 - 01/2011
2Biomarkers (Surrogate Marker)IBA
08/2021 - 03/2012
2NF-kappa B (NF-kB)IBA
09/2016 - 07/2010
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2016 - 07/2012
2Matrix Metalloproteinases (MMPs)IBA
01/2016 - 04/2015
2tempolIBA
06/2015 - 01/2012
2Phosphotransferases (Kinase)IBA
01/2015 - 11/2012
2Uncoupling Protein 2IBA
07/2012 - 10/2009
2Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA
04/2012 - 01/2011
2Proteasome Endopeptidase Complex (Proteasome)IBA
04/2012 - 01/2011
2Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2012 - 10/2010
2OligonucleotidesIBA
01/2012 - 07/2005
2Superoxide DismutaseIBA
01/2012 - 02/2009
2NADPH Oxidases (NAD(P)H oxidase)IBA
01/2012 - 02/2009
2Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
03/2011 - 07/2005
2Heme Oxygenase-1IBA
03/2011 - 12/2009
2Oxygen (Dioxygen)IBA
01/2011 - 05/2005
2Adenosine Triphosphate (ATP)IBA
11/2009 - 04/2005
2Electron Transport Complex IV (Cytochrome c Oxidase)IBA
04/2005 - 01/2002
2Oxidoreductases (Dehydrogenase)IBA
10/2004 - 01/2002
2NAD (NADH)IBA
10/2004 - 01/2002
1Amyloid (Amyloid Fibrils)IBA
07/2021
1VitaminsIBA
08/2020
1Anticonvulsants (Antiepileptic Drugs)IBA
08/2020
1Small Interfering RNA (siRNA)IBA
09/2017
1EverolimusFDA Link
10/2016
1IrbesartanFDA LinkGeneric
10/2016
1CollagenIBA
01/2016
1Doxycycline (Periostat)FDA LinkGeneric
01/2016
1E-SelectinIBA
11/2015
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
11/2015
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
11/2015
1Interleukin-6 (Interleukin 6)IBA
06/2015
1N- (2- cyclohexyloxy- 4- nitrophenyl)methanesulfonamideIBA
06/2015
1CytokinesIBA
06/2015
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2015
170-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
03/2015
1TOR Serine-Threonine KinasesIBA
03/2015
1Peptide Initiation Factors (Initiation Factor)IBA
03/2015
1Protein Kinases (Protein Kinase)IBA
03/2015
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
01/2015
1aliskirenFDA Link
11/2014
1AngiotensinsIBA
11/2014
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
11/2014
1ChemokinesIBA
11/2014
1CC ChemokinesIBA
11/2014
1Renin InhibitorsIBA
11/2014
1Glucose (Dextrose)FDA LinkGeneric
06/2014
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
02/2014
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2013

Therapy/Procedure

6Intravenous Administration
04/2012 - 05/2003
3Therapeutics
08/2020 - 05/2005
3Catheters
08/2011 - 05/2005
3Anesthesia
01/2009 - 04/2004
1Chemoradiotherapy
03/2015
1Intraventricular Infusions
11/2013